Insomniac Presents the 4th Annual Beyond Wonderland Festival Lineup

first_imgFor the fourth consecutive year in a row Insomniac is taking Californians down the rabbit hold with Beyond Wonderland on March 13th. Located in the San Manuel Amphitheater & Grounds in San Bernadino, California. This location has hosted several major events including Ozzfest and Mayhem Festival. However, this is the first year the Southern California festival will be hosted at this expansive venue.  Artist line up is to include: Afrojack, Bassjackers, Camo & Krooked, Chuckie, Crizzly, Dash Berlin, David Guetta, Delta Heavy, High Contrast, Markus Schulz, R3hab, Trent Cantrelle, + more.Beyond Wonderland is an 18 and older event.  General admission tickets are priced at $65, and VIP tickets are also available for guests 21 and older at $150, before service fees. VIP amenities include a separate entrance to the festival for expedited access; VIP Decks overlooking stage including a full cash bar; private restroom facilities; and souvenir laminate and lanyard. The venue is “Surrounded by rolling hills and mountains, we will transform the grounds like never before with multiple stages, new features, large scale art installations and roaming performers.” Tickets and full line-up are available now at www.beyondwonderland.com.Full Lineup:AfrojackArt DepartmentArtyBassjackersBassrush ExperienceBlake JarrellCamo & KrookedChuckieCrizzlyCulture ShockDamian LazarusDarin EpsilonDash BerlinDavid GuettaDavid StevenDelta HeavyDiscovery ProjectDymanite MCEd Rush & OpticalFrancesca LombardoFred V & GrafixHigh ContrastJulian JordanMaceo PlexMarkus SchulzMatrix & FutureboundMaya Jane ColesMr. WhiiiteR3habRebecca & FionaState of MindSteve AngelloSubb-AnTrent CantrelleUmekW&WWide Awake Art Carlast_img read more

Read more →

Watch As Bill Murray Sings Three Minutes of Bob Dylan’s ‘Shelter From The Storm’

first_imgLet’s face it; we all love Bill Murray. Between the renowned actor’s starring roles and public antics, Murray is a beloved figure.Thus, when we found this clip of Murray singing along to some Bob Dylan for his titular role in the upcoming film St. Vincent, we just had to share. Murray sings three minutes of “Shelter From The Storm,” a track from Dylan’s 1975 album Blood On The Tracks.Watch below:St. Vincent comes out next Friday, October 10th. We’re certainly curious to see how this intimate cut fits into the film.[Via Consequence of Sound]last_img read more

Read more →

How are Experts Tracking Variants of the Coronavirus?

first_img“If we don’t know these things, we’re running blind,” said Sara Vetter, assistant lab director for the Minnesota Department of Health. Viruses can mutate as they make copies of themselves after infecting a person. By sequencing virus samples over time, scientists can look for recurring changes in the genome. Evidence suggests that current vaccines still work against the variants though perhaps not as well against a mutated version that first appeared in South Africa. Scientists are scanning virus samples taken from infected people to look for mutations, through a process called genome sequencing. It’s the same method researchers have been using for years to study bacteria, plants, animals and humans. Most mutations are meaningless, but others can make a virus more contagious, deadly or resistant to vaccines and treatment. Health experts are primarily concerned about three variants first detected in the United Kingdom, South Africa and Brazil. They seem to spread more easily and research is underway to see if they cause more serious disease. How are experts tracking variants of the coronavirus? (AP Illustration/Peter Hamlin) center_img By MARION RENAULT Associated Press How are experts tracking variants of the coronavirus? Around the world, researchers have sequenced more than 500,000 genomes of the COVID-19 virus to date. Countries vary in their genomic surveillance. Britain, for example, sequences about 10% of specimens positive for the coronavirus, compared to less than 1% in the U.S.last_img read more

Read more →

CCIM Institute certification’s return of investment

first_imgScott FeyOp-Ed by Scott Fey, CCIM, Principal, Omni-American LLCThe Certified Commercial Investment Member (CCIM) Institute was established in 1954 to give commercial real estate practitioners a previously unrealized opportunity to further their business practices through focused education and networking opportunities. Today, with the addition of advanced technology tools, CCIM is the global leader in commercial and investment real estate education and services. A CCIM designee is a recognized expert in the commercial and investment real estate industry and proficient in both theory and practice. Brokers, lending professionals, investment counselors, asset managers, appraisers, corporate real estate executives, developers, institutional investors, commercial leaders, attorneys, bankers and all other allied professionals can all fall under this category having achieved the CCIM designation.The CCIM certification requires that a designee follow strictest ethical guidelines and standards of practice in the commercial real estate industry. The CCIM Institute is committed to high standards of ethical business practice and ethics are strongly enforced and reiterated to students. To achieve the CCIM designation candidates must successfully complete a graduate level program of 160 hours of classroom education. Many companies and real estate professionals are more likely to seek out experts with CCIM designation because of CCIM’s reputation for trust, knowledge and reliability.Classes challenge attendees to test their knowledge to expand their thoughts in order to become a successful CCIM. The classes provide instrumental knowledge in areas such as internal rate of return, discounted cash flow, lease analysis, application of financing to investment, capitalization rate, market analysis, tax calculation, time value of money, and net present value among others. A majority of the financial analysis and CCIM developed investment analysis spreadsheets are provided in the first class study, CI 101, to set a solid foundation.According to Central Arizona Chapter President, Scott Fey, CCIM who was a Principal at Omni American, LLC, “The essential analysis tools provided by each of the four core CCIM classes are invaluable in today’s marketplace. The spreadsheets provide instant analysis of complex commercial real estate possibilities and allow you to determine if the proposition is valuable or needs adjustment.” Fey is an avid user of the CCIM Site To Do Business in order to determine where to buy land for the company’s projects.The CCIM Institute has been refining and changing the core educational program as change occurs in the industry. All four core classes have evolved over time to meet the challenges of the US commercial real estate and the world commercial real estate markets. The Institute also provides a robust program of continued real estate after the completion of the four core classes. Some of the continuing class offerings include; before and after tax discounted cash flow, commercial real estate negotiations, development demand studies and more. The core CCIM class room program is taught in the United States and internationally, with over 50 chapters worldwide.last_img read more

Read more →

Neuroscience study finds the brain’s response to emotional conflict predicts antidepressant treatment outcomes

first_imgLinkedIn “Prior to this study, it has been unclear whether the apparent small difference in treatment outcome between antidepressants and placebo historically have been due to problems with the medications (i.e. they are not particularly effective) or problems with the diagnosis (i.e. definition of the disorder in broad clinical terms lumps together people with very different biology.)”The researchers examined functional magnetic resonance imaging (fMRI) data from the EMBARC trial. “EMBARC is by far the largest placebo-controlled neuroimaging study of antidepressants,” Etkin said.The trial randomly assigned 309 depressed outpatients to receive either the selective serotonin reuptake inhibitor sertraline or placebo for 8 weeks.The participants also underwent brain imaging prior to treatment, during which they were shown photographs in quick succession that offered sometimes conflicting messages such as an fearful face with the word “happy” or a smiling face with the word “fear.” The participants were instructed to identify the facial emotion with a key press, while trying to ignore the word.The researchers then used machine learning analyses to identify specific brain regions that predicted whether participants would benefit from the SSRI treatment. The results showed that participants who had abnormal neural responses during emotional conflict were less likely to improve within eight weeks of starting the medication.“We found two very interesting things. First, it was very clear from our results that there are strong biological reasons for why a depressed patient responds to an antidepressant versus to a placebo,” Etkin told PsyPost.“In other words, it seems that it is the catch-all way we make the clinical diagnosis of depression that is imprecise, and there are people for whom antidepressants work much better than placebo but others for whom there is no such difference. We were able to define these brain signatures in people using both conventional and machine learning analyses.”“Second, we found that the reason people respond better to an antidepressant is that they seem to be better able to regulate emotion processing in an automatic manner. The better their brains did this, the greater the difference between the antidepressant and placebo,” Etkin explained.Another analysis of EMBARC data, published in the American Journal of Psychiatry, found that patterns of functional connectivity in the brain “appear to play an important role in identifying a favorable response for a drug treatment for major depressive disorder.”But there is still a need for more research.“As with any study, even one of a large population of patients studied over the course of a very detailed and exhaustive study, replication is needed to confirm the results. Such replications are unlikely to take the same form as EMBARC, which was a costly and effort-intensive study, and thus care must be taken to make sure that we progressively learn through each attempt at extension and generalization of these findings,” Etkin said.“It would be nice in future work to see whether this kind of signal can be found with more clinic-ready brain imaging tools, such as EEG. Likewise, we have only started to scratch the surface of what it is that makes medication responders different from those who do not respond to medication, and thus a lot more work is needed at multiple levels (genetics, behavior, sleep, etc.)”“Nonetheless, the general message from this paper is that it does seem that the imprecision inherent in our diagnoses is in large part to blame for the poor outcomes of the trial-and-error approach we currently rely on in psychiatric treatment,” Etkin concluded.The study, “Brain regulation of emotional conflict predicts antidepressant treatment response for depression“, was authored by Gregory A. Fonzo, Amit Etkin, Yu Zhang, Wei Wu, Crystal Cooper, Cherise Chin-Fatt, Manish K. Jha, Joseph Trombello, Thilo Deckersbach, Phil Adams, Melvin McInnis, Patrick J. McGrath, Myrna M. Weissman, Maurizio Fava, and Madhukar H. Trivedi. Share on Facebook Pinterest Share on Twittercenter_img Neuroimaging data from a large randomized controlled trial indicates that how people respond to antidepressant medication is predicted by how their brain processes conflicting emotional information. The findings have been published in Nature Human Behaviour.“This study addressed two questions central to the ability to meaningfully use biology to understand and guide psychiatric treatment and drug development,” said study author Amit Etkin, the founder and CEO of Alto Neuroscience as well as a professor at Stanford University.“One was whether there are identifiable biological differences between patients with depression that determine who responds to an antidepressant compared to a placebo. The second was what role emotion regulation plays in defining those biological attributes.” Share Emaillast_img read more

Read more →

News Scan for Oct 27, 2016

first_imgTortilla chips blamed for GI illness outbreak at Wyoming prisonIn today’s Morbidity and Mortality Weekly Report, the Centers for Disease Control and Prevention (CDC) and local health officials said rancid tortilla chips were to blame for an outbreak of gastrointestinal illness that sickened 79 workers and inmates at a correctional facility in Wyoming a year ago.The patients fell ill 1 to 3 hours after eating lunch on Oct 11, 2015, and reported gas, bloating, and diarrhea (70% of patients) and vomiting (21%). Within 3 weeks of the outbreak, the Wyoming Department of Health and county health department conducted a case-control study to identify the outbreak source.Epidemiologic investigation pointed to tortilla chips as the only food associated with the illness, and markers for rancidity (hexanal and peroxide) were found in the chips through composite food samples. There was no evidence of an infectious source or chemical agent. Very few case-control studies exist that prove that rancidity, caused by the decomposition of oils and fats, can lead to gastrointestinal illness.”This outbreak serves as a reminder to consider alternative food testing methods during outbreaks of unusual gastrointestinal illness when typical foodborne pathogens are not identified,” the authors said.Oct 27 MMWR study WHO: 1 million successfully treated for hepatitis C with new drugsThe World Health Organization (WHO) in a report today titled, Global Report on Access to Hepatitis C Treatment: Focus on Overcoming Barriers, said 1 million people in low and middle-income countries have been successfully treated for hepatitis C with a new class of drugs, direct-acting antivirals (DAAs).When the drugs were introduced in 2013, many critics feared DAAs were too expensive for poorer countries, and would fail to reach the 80 million people who have chronic hepatitis C worldwide. Through cost-lowering strategies, such as competition from generic medicines through licensing agreements, local production, and price negotiations, the WHO said some member states were able to offer wider access to the drug.Costs for the drug vary greatly: Some countries, such as Romania, price a 3-month course of DAAs at almost $80,000. But other countries, such as Egypt, used local production and dropped their cost from $900 in 2014 to less than $200 in 2016, the report said.Hepatic C kills 700,000 people each year. DAAs have a cure rate of 95%, but their high costs have led to restricted use in even high-income countries. Earlier this year, the World Health Assembly said that its goal for viral hepatitis was to treat 80% of infected people by 2030.Oct 27 WHO press release C Diff DNA found on hospital surfaces during outbreakIn a study today in the American Journal of Infection Control, the authors found Clostridium difficile DNA on 71% of hospital surfaces during a C difficile outbreak, and on 28% of the surfaces 2 years after the outbreak ended.The disease is easily spread in hospitals because its spores are resistant to most disinfectants. The bacteria can also live on inert surfaces and is one of the leading causes of diarrhea in elderly hospital patients.From January through July 2009, a C difficile outbreak linked to a mortality rate of 11% occurred in a Costa Rican general hospital. Twenty-four surface samples were collected during the outbreak, with another 54 surface samples collected 2 years later. Overall, C difficile DNAwas detected in 40% of the 75 environmental samples, with a 2.5-fold increase during the outbreak.About 67% of bedrails and walls were C difficile–positive during the outbreak.”These results reinforce the relevance of strict hygiene procedures and cleaning measures in the control of C difficile infections in hospitals, even in the absence of outbreaks,” the authors concluded.Oct 27 Am J Infect Control studylast_img read more

Read more →

Demaco to supply cryogenic equipment to DESY

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

Read more →

DOF Subsea and Technip Win Petrobras Contract

first_imgDOF Subsea and Technip joint venture has secured a contract with Brazilian oil major Petrobras for the vessel Skandi Niterói.The Skandi Niteroi is designed for pipelay, subsea construction, installation and maintenance work and can operate in up to 2,300 meters water depths.According DOF, the contract with immediate effect will last for about 8 months firm and with 8 months options..Mons S. Aase, CEO, stated: “I am very pleased with the contract award, securing utilization in a challenging market and maintaining our strong position in the Brazilian market.”The 142 meters long Brazilian-flagged vessel joined the Technip/DOF fleet in 2011.The Skandi Niteroi is equipped with a vertical and horizontal pipelay system, a 2,000 Te under-deck carousel , and 1,400 Te reels. The vesses also has two work-class ROVs, and a 250 Te active-heave compensated crane.Subsea World News Stafflast_img read more

Read more →

SCS handles heavy jack up

first_imgThe company deployed eight 300-tonne jacks, eight 500-tonne jacks, 400 m hydraulic hoses, 200 m of data cable and three cases of small equipment to complete the job, which was required before the units were installed offshore.Both parts were jacked up using SCS’ computer controlled synchronised lifting system. “This system uses feedback from multiple sensors to control the lifting, lowering and positioning of any large, heavy or complex structure regardless of weight distribution, therefore reducing the risk of bending, twisting or tilting,” explained managing director of SCS, Robin van der Stigchel.The jacket had the dimensions 23 m x 27 m x 85 m, and the topside had the dimensions 34 m x 23 m x 13 m.The units are parts of the Hilal B platform, which is located in the Shoab Ali field in the Gulf of Suez.  www.scsheavy.comlast_img read more

Read more →

Johnson Renew finalises lifts

first_imgJohnson Renew was contracted to supply cranes and support services for installation of 67 wind turbines for the Longyuan Mulilo De Aar Maanhaarberg Wind Energy Facility. The 96.5 MW facility is being constructed by Longyuan Engineering South Africa, a subsidiary of China Longyuan.The turbine components, which are supplied from China by Guodian United Power Corporation, have been offloaded on to installation pads and lifted using a 250-tonne capacity mobile crane. The pre-installation of the bottom tower sections has been executed using a combination of a 550-tonne capacity crane and a 100-tonne capacity crane, while the main installation lifting has been done with a LTR 11200, a 1,200-tonne capacity hydraulic crawler crane with a 100 m hydraulic boom, used in combination with a 100-tonne capacity crane.According to Johnson Crane Hire, Johnson Renew was established to grow its presence in the wind energy market, as well as other key renewable energy projects.   www.jch.co.zawww.jrsa.co.zalast_img read more

Read more →